Sylvester Comprehensive Cancer Center, University of Miami, FL
I am the Physician-in-Chief, Oncology Service Line at the Sylvester Cancer Center and Professor of Medicine at the Miller School of Medicine, University of Miami Health System.
My research has focused on improving the outcome of patients with poor risk Hodgkin lymphoma (HL) and diffuse large B cell lymphoma (DLBCL). This effort has been conducted along two tracks: 1) optimizing therapy for patients with relapsed and refractory disease, including high dose therapy (HDT) and autologous stem cell transplant (ASCT) and studying new agents that can be incorporated into salvage therapy, and 2) developing risk-adapted strategies to optimize the treatment of newly diagnosed DLBCL and Hodgkin’s Lymphoma by using what we have learned in the relapsed and refractory setting. This research has led to changes in standard of care that include PET-adapted therapies, maintenance therapy post-ASCT, utility of clinical and molecular-derived prognostic models in the relapsed and refractory setting, and the incorporation of novel immune-based approaches in the second-line setting. Two agents were approved during these clinical investigations: Brentuximab Vedotin for maintenance therapy post-ASCT for Hodgkin lymphoma and Pembrolizumab for palliation of poor risk Hodgkin lymphoma.
Prior to coming to the Sylvester Comprehensive Cancer Center, I practiced for 25 years at Memorial Sloan Kettering Cancer Center in New York, where I directed the division of Hematologic Oncology and had an endowed chair in lymphoma research. I have mentored 24 clinical researchers who care for patients with lymphoma and leukemia and are currently practicing at various institutions in the U.S.