Rafet Basar

MD Anderson Cancer Center, TX, USA

I received my MD degree in Turkey in 2009 and completed my residency in Internal Medicine at the Istanbul Faculty of Medicine in 2015. Following my clinical training, I began my research training as a post-doctoral research fellow in Stem Cell Transplantation and Cellular Therapy department in the Division of Cancer Medicine under the mentorship of Dr. Katayoun Rezvani to focus on adoptive cellular therapy and cancer immunology. Throughout my postdoctoral career at MD Anderson Cancer Center my work has been dedicated to developing innovative methods to enhance the potency of NK cellular therapy products using state of the art genetic engineering strategies for the treatment of hematologic malignancies, engineering cytotoxic T cells to treat post-transplant viral infections and characterizing B cells for the purpose of viable expansion and suppression along with their role in the tumor mileu. I have developed a novel strategy combining chimeric antigen receptor (CAR) engineering with CRISPR Cas9 multiplex gene editing to knock out multiple inhibitory molecules simultaneously such as TGFBRII, CISH and NKG2A, for the generation of highly potent cells for cancer immunotherapy.